Abstract Background: The escalating challenge of antifungal resistance and the side effects associated with conventional drugs have intensified the search for natural alternatives. This study investigated the efficacy of Syzygium aromaticum (clove) extracts compared to standard antifungal agents against clinical oral Candida isolates from Libyan patients. Methods: Five Candida species (C. albicans, C. glabrata, C. krusei, C. parapsilosis, C. tropicalis) were isolated from patients in Gharyan City, Libya. The antifungal susceptibility to Amphotericin B, Miconazole and Nystatin was tested using the disc diffusion method. The activity of aqueous and alcoholic clove extracts (25%, 50%, 100%) and pure clove oil (Eugenol) was evaluated using a welldiffusion assay.